Nature Communications (Jul 2022)
Modulating mitofusins to control mitochondrial function and signaling
- Emmanouil Zacharioudakis,
- Bogos Agianian,
- Vasantha Kumar MV,
- Nikolaos Biris,
- Thomas P. Garner,
- Inna Rabinovich-Nikitin,
- Amanda T. Ouchida,
- Victoria Margulets,
- Lars Ulrik Nordstrøm,
- Joel S. Riley,
- Igor Dolgalev,
- Yun Chen,
- Andre J. H. Wittig,
- Ryan Pekson,
- Chris Mathew,
- Peter Wei,
- Aristotelis Tsirigos,
- Stephen W. G. Tait,
- Lorrie A. Kirshenbaum,
- Richard N. Kitsis,
- Evripidis Gavathiotis
Affiliations
- Emmanouil Zacharioudakis
- Department of Biochemistry, Albert Einstein College of Medicine
- Bogos Agianian
- Department of Biochemistry, Albert Einstein College of Medicine
- Vasantha Kumar MV
- Department of Biochemistry, Albert Einstein College of Medicine
- Nikolaos Biris
- Department of Biochemistry, Albert Einstein College of Medicine
- Thomas P. Garner
- Department of Biochemistry, Albert Einstein College of Medicine
- Inna Rabinovich-Nikitin
- Department of Physiology and Pathophysiology, Max Rady College of Medicine, Faculty of Health Sciences, University of Manitoba
- Amanda T. Ouchida
- Department of Biochemistry, Albert Einstein College of Medicine
- Victoria Margulets
- Department of Physiology and Pathophysiology, Max Rady College of Medicine, Faculty of Health Sciences, University of Manitoba
- Lars Ulrik Nordstrøm
- Department of Biochemistry, Albert Einstein College of Medicine
- Joel S. Riley
- Cancer Research UK Beatson Institute
- Igor Dolgalev
- Department of Pathology, New York University School of Medicine
- Yun Chen
- Department of Medicine, Albert Einstein College of Medicine
- Andre J. H. Wittig
- Department of Medicine, Albert Einstein College of Medicine
- Ryan Pekson
- Department of Medicine, Albert Einstein College of Medicine
- Chris Mathew
- Department of Biochemistry, Albert Einstein College of Medicine
- Peter Wei
- Department of Biochemistry, Albert Einstein College of Medicine
- Aristotelis Tsirigos
- Department of Pathology, New York University School of Medicine
- Stephen W. G. Tait
- Cancer Research UK Beatson Institute
- Lorrie A. Kirshenbaum
- Department of Physiology and Pathophysiology, Max Rady College of Medicine, Faculty of Health Sciences, University of Manitoba
- Richard N. Kitsis
- Department of Medicine, Albert Einstein College of Medicine
- Evripidis Gavathiotis
- Department of Biochemistry, Albert Einstein College of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-31324-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Mitofusins regulate mitochondrial fusion. Here the authors identify small molecules that activate or inhibit mitofusins’ activity and modulate mitochondrial fusion and functionality. Inhibition of mitochondrial fusion promotes minority MOMP, caspase-3/7 activation, and DNA damage.
