Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation

Oscar Ortega-Recalde; Robert C. Day; Neil J. Gemmell; Timothy A. Hore

doi:10.1038/s41467-019-10894-7

Nature Communications (Jul 2019)

Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation

Oscar Ortega-Recalde,
Robert C. Day,
Neil J. Gemmell,
Timothy A. Hore

Affiliations

Oscar Ortega-Recalde: Department of Anatomy, University of Otago
Robert C. Day: Department of Biochemistry, University of Otago
Neil J. Gemmell: Department of Anatomy, University of Otago
Timothy A. Hore: Department of Anatomy, University of Otago

DOI: https://doi.org/10.1038/s41467-019-10894-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Germline cells transfer genetic information to offspring, and in zebrafish, drive sex determination. Here the authors report that, unlike mammals, the germline of zebrafish does not undergo genome-wide DNA methylation erasure, while amplifying and demethylating sex-linked rDNA during feminisation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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