Enzymatic enhancing of triplet–triplet annihilation upconversion by breaking oxygen quenching for background-free biological sensing

Ling Huang; Timmy Le; Kai Huang; Gang Han

doi:10.1038/s41467-021-22282-1

Nature Communications (Mar 2021)

Enzymatic enhancing of triplet–triplet annihilation upconversion by breaking oxygen quenching for background-free biological sensing

Ling Huang,
Timmy Le,
Kai Huang,
Gang Han

Affiliations

Ling Huang: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
Timmy Le: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
Kai Huang: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
Gang Han: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School

DOI: https://doi.org/10.1038/s41467-021-22282-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Triplet-triplet annihilation upconversion (TTA-UC) nanoparticles (NPs) are a promising material for diverse applications, but TTA-UC is sensitive to oxygen, which hinders its biological utility. Here, the authors report an enzymatic method to deplete oxygen and amplify the upconversion of TTA-UCNP in aqueous solution, and develop background-free glucose and glucose metabolism enzyme sensors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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