Nature Communications (Jul 2022)
Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy
- Mary Prahl,
- Yarden Golan,
- Arianna G. Cassidy,
- Yusuke Matsui,
- Lin Li,
- Bonny Alvarenga,
- Hao Chen,
- Unurzul Jigmeddagva,
- Christine Y. Lin,
- Veronica J. Gonzalez,
- Megan A. Chidboy,
- Lakshmi Warrier,
- Sirirak Buarpung,
- Amy P. Murtha,
- Valerie J. Flaherman,
- Warner C. Greene,
- Alan H. B. Wu,
- Kara L. Lynch,
- Jayant Rajan,
- Stephanie L. Gaw
Affiliations
- Mary Prahl
- Department of Pediatrics, University of California
- Yarden Golan
- Department of Bioengineering and Therapeutic Sciences, University of California
- Arianna G. Cassidy
- Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco
- Yusuke Matsui
- Gladstone Center for HIV Cure Research, Gladstone Institute
- Lin Li
- Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco
- Bonny Alvarenga
- Department of Neurology, University of California
- Hao Chen
- Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco
- Unurzul Jigmeddagva
- Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco
- Christine Y. Lin
- Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco
- Veronica J. Gonzalez
- Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco
- Megan A. Chidboy
- Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco
- Lakshmi Warrier
- Department of Medicine, University of California
- Sirirak Buarpung
- Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco
- Amy P. Murtha
- Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco
- Valerie J. Flaherman
- Department of Pediatrics, University of California
- Warner C. Greene
- Gladstone Center for HIV Cure Research, Gladstone Institute
- Alan H. B. Wu
- Department of Laboratory Medicine, University of California
- Kara L. Lynch
- Department of Laboratory Medicine, University of California
- Jayant Rajan
- Department of Medicine, University of California
- Stephanie L. Gaw
- Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco
- DOI
- https://doi.org/10.1038/s41467-022-32188-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Pregnant individuals are at higher risk of SARS-CoV-2-related morbidity and mortality, yet more studies are needed to evaluate safety and efficacy of vaccination during pregnancy, and also the level of protection provided to the newborn. Here, the authors evaluate transplacental transfer of mRNA vaccine products and functional SARS-CoV-2 antibodies during pregnancy and early infancy.
