Our experience with activated glycyrrhizinic acid (AGA) as monotherapy for the inflammatory disease of cervix uteri

Abstract

Zh.A. Mandrykina, L.V. Saprykina, M.R. Narimanova Pirogov Russian National Research Medical University, Moscow, Russian Federation Inflammatory disease of cervix uteri (N72 code, ICD-10) is caused by specific and non-specific microbes as well as by various mechanical and chemical factors (irrigation, barrier contraceptives etc.) which result in cervical epithelium damage and impaired local immunity. In these cases, inflammatory disease of cervix uteri persists despite repeated courses of antibacterial treatment. Young women and teenagers have higher risks due to the cervical immaturity, physiological ectopia of endocervical epithelium, and increased sensitivity to the external stimuli including sexually transmitted infections and human papillomavirus. We carried out a pilot study to assess the efficacy and safety of activated glycyrrhizinic acid (AGA) as monotherapy for the inflammatory disease of cervix uteri. This study has included 24 women of pre- and perimenopausal age (mean age 41.8±8.2 years) with the inflammatory disease of cervix uteri. Major complaints were genital discomfort, itching, an d burning. No sexually transmitted infections or diagnostically relevant levels of opportunistic microbes were identified by real-time PCR in a total of 24 women. All women received intravaginal AGA as monotherapy. Treatment efficacy was assessed by the improvement/relief of complaints as well as by colposcopic improvement. Descriptive statistics was applied to analyze demographic and clinical data. After 14 days, none of 24 women presented with complaints of genital discomfort, itching, and burning. No adverse side effects were reported. Colposcopy has demonstrated reduced ectopic area borders in 100% of women and more uniform staining with Lugol’s solution. In women with the inflammatory disease of cervix uteri but no sexually transmitted infections or diagnostically relevant levels of opportunistic microbes, local treatment with AGA is an effective and safe therapeutic modality. AGA as monotherapy improves the  symptoms of the inflammatory disease of cervix uteri withi n 7 days as well as colposcopy results. Keywords: cervicitis, inflammatory disease of cervix uteri, activated glycyrrhizinic acid, reproductive age, perimenopausal age, treatment, diagnostics, colposcopy, opportunistic microbes, sexually transmitted infections, immunostimulating activity, monotherapy. For citation: Mandrykina Zh.A., Saprykina L.V., Narimanova M.R. Our experience with activated glycyrrhizinic acid (AGA) as monotherapy for the inflammatory disease of cervix uteri. Russian Journal of Woman and Child Health. 2019;2(3):249–253.