Research progress in MACC1 and cancer

Abstract

The occurrence of malignant tumor is a serious threat to human health and survival, but its pathogenesis and metastasis mechanism are still not very clear. MACC1 is a gene that was found in 2009 to be closely related to the development of colon cancer. The consensus is that MACC1 not only induces the occurrence and metastasis of tumors, but also significantly correlates with the prognosis and survival rate of tumor patients, which is mainly related to the regulation of HGF/c-Met signaling pathway by MACC1. MACC1 is expected to be a new target for tumor gene therapy in the future. In this review, the research progress of MACC1 in the process of tumor development and metastasis was reviewed.

Keywords

• metastasis-associated in colon cancer 1
• hgf / c-met signaling pathway
• tumor metastasis
• gene therapy