Extract of Edible Mushroom <i>Laetiporus sulphureus</i> Affects the Redox Status and Motility of Colorectal and Cervical Cancer Cell Lines

Abstract

Colorectal and cervical cancer are major health problems worldwide, and adjuvant therapy, which uses fungi, is considered valuable in cancer treatment. Herein, we evaluated effects of edible mushroom species Laetiporus sulphureus on the viability, redox status, and motility of two different cancer cell lines. Treatment induced oxidative stress and inhibition of migratory potential in both tested cell lines, showing cell selective activity and affecting HCT-116 and HeLa cells in a different manner. However, the presented effects of this mushroom should not be neglected in future studies, especially detailed studies on drug development.

Keywords

• migration
• <i>Laetiporus sulphureus</i>
• cancer
• redox status