m6Am-seq reveals the dynamic m6Am methylation in the human transcriptome

Hanxiao Sun; Kai Li; Xiaoting Zhang; Jun’e Liu; Meiling Zhang; Haowei Meng; Chengqi Yi

doi:10.1038/s41467-021-25105-5

Nature Communications (Aug 2021)

m6Am-seq reveals the dynamic m6Am methylation in the human transcriptome

Hanxiao Sun,
Kai Li,
Xiaoting Zhang,
Jun’e Liu,
Meiling Zhang,
Haowei Meng,
Chengqi Yi

Affiliations

Hanxiao Sun: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Kai Li: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Xiaoting Zhang: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Jun’e Liu: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Meiling Zhang: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Haowei Meng: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Chengqi Yi: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University

DOI: https://doi.org/10.1038/s41467-021-25105-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

m6Am is a dynamic and reversible RNA modification found on the mRNA cap. Here the authors report m6Am-seq to directly distinguish m6Am from m6A and identify functional methylation sites.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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