FEATURES OF THE FORMATION OF FATTY LIVER DEGENERATION IN CHRONIC EXPOSURE TO TOXIC FIRE PRODUCTS IN FIREFIGHTERS

Abstract

Background. The profession of firefighters is characterized by the impact of a number of dangerous factors, including toxic fire products, which is currently not taken into account by the medical service and medical and psychological support units. To increase the effectiveness of measures aimed at preventing non-communicable diseases, protecting the health and improving the professional longevity of firefighters, it is necessary to take into account the influence of harmful professional factors that influence the formation of various pathologies. Intention of the study: to determine laboratory parameters characterizing the toxic etiology of the formation of fatty liver degeneration in firefighters. Methodology. To determine the features of the pathogenesis of non-alcoholic fatty liver disease, 246 male patients suffering and not suffering from fatty liver degeneration were examined. The tasks were solved by analyzing the results obtained using toxicological, biochemical, and immunological techniques. Results and Discussion. Laboratory markers of fatty liver degeneration have been determined. The peculiarities of the regulation of the immune system in employees of the GPS FPS of the Ministry of Emergency Situations of Russia suffering from fatty liver degeneration have been revealed. Conclusions. Multidirectional changes in instrumental, biochemical and immunological parameters were revealed in firefighters suffering from fatty liver degeneration compared to the control group with the same pathology, indicating the peculiarities of homeostasis disorders, which determines the difference in pathogenesis caused by chronic toxic damage by fire products.

Keywords

• fire toxic products
• dioxins
• microbiota
• dysbiosis
• immune status
• fatty liver degeneration
• pathogenesis
• firefighters