RN7SK small nuclear RNA controls bidirectional transcription of highly expressed gene pairs in skin

Roberto Bandiera; Rebecca E. Wagner; Thiago Britto-Borges; Christoph Dieterich; Sabine Dietmann; Susanne Bornelöv; Michaela Frye

doi:10.1038/s41467-021-26083-4

Nature Communications (Oct 2021)

RN7SK small nuclear RNA controls bidirectional transcription of highly expressed gene pairs in skin

Roberto Bandiera,
Rebecca E. Wagner,
Thiago Britto-Borges,
Christoph Dieterich,
Sabine Dietmann,
Susanne Bornelöv,
Michaela Frye

Affiliations

Roberto Bandiera: Department of Genetics, University of Cambridge
Rebecca E. Wagner: German Cancer Research Center—Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280
Thiago Britto-Borges: University Hospital Heidelberg, German Center for Cardiovascular Research (DZHK), Im Neuenheimer Feld 669
Christoph Dieterich: University Hospital Heidelberg, German Center for Cardiovascular Research (DZHK), Im Neuenheimer Feld 669
Sabine Dietmann: Washington University School of Medicine in St. Louis
Susanne Bornelöv: Wellcome–MRC Cambridge Stem Cell Institute, University of Cambridge
Michaela Frye: German Cancer Research Center—Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280

DOI: https://doi.org/10.1038/s41467-021-26083-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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The noncoding RNA RN7SK regulates RNA polymerase II pausing and splicing. Here the authors deplete RN7SK in mouse and human during epidermal stem cell differentiation and reveal a novel role in orchestrating bidirectional transcription of highly expressed gene pairs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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