Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblasts

Eleonora Timperi; Emanuela Romano; Emanuela Romano

doi:10.3389/fimmu.2023.1194642

Frontiers in Immunology (Jun 2023)

Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblasts

Eleonora Timperi,
Emanuela Romano,
Emanuela Romano

Affiliations

Eleonora Timperi: Department of Immunology, INSERM U932, Université Paris Sciences et Lettres (PSL) Research University, Institut Curie, Paris, France
Emanuela Romano: Department of Immunology, INSERM U932, Université Paris Sciences et Lettres (PSL) Research University, Institut Curie, Paris, France
Emanuela Romano: Department of Medical Oncology, Center for Cancer Immunotherapy, Institut Curie, Paris, France

DOI: https://doi.org/10.3389/fimmu.2023.1194642
Journal volume & issue: Vol. 14

Abstract

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The tumor associated macrophages (TAM) represent one of most abundant subpopulations across several solid cancers and their number/frequency is associated with a poor clinical outcome. It has been clearly demonstrated that stromal cells, such as the cancer associated fibroblasts (CAFs), may orchestrate TAM recruitment, survival and reprogramming. Today, single cell-RNA sequencing (sc-RNA seq) technologies allowed a more granular knowledge about TAMs and CAFs phenotypical and functional programs. In this mini-review we discuss the recent discoveries in the sc-RNA seq field focusing on TAM and CAF identity and their crosstalk in the tumor microenvironment (TME) of solid cancers.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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