Frontiers in Cell and Developmental Biology (Oct 2021)
Extracellular Vesicles Regulated by Viruses and Antiviral Strategies
- Li Yang,
- Li Yang,
- Li Yang,
- Li Yang,
- Jing Li,
- Jing Li,
- Jing Li,
- Jing Li,
- Shen Li,
- Shen Li,
- Shen Li,
- Shen Li,
- Wei Dang,
- Wei Dang,
- Wei Dang,
- Wei Dang,
- Shuyu Xin,
- Shuyu Xin,
- Shuyu Xin,
- Shuyu Xin,
- Sijing Long,
- Sijing Long,
- Sijing Long,
- Sijing Long,
- Wentao Zhang,
- Wentao Zhang,
- Wentao Zhang,
- Wentao Zhang,
- Pengfei Cao,
- Pengfei Cao,
- Pengfei Cao,
- Jianhong Lu,
- Jianhong Lu,
- Jianhong Lu,
- Jianhong Lu
Affiliations
- Li Yang
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Li Yang
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Li Yang
- National Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Li Yang
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Jing Li
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Jing Li
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Jing Li
- National Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Jing Li
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Shen Li
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Shen Li
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Shen Li
- National Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Shen Li
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Wei Dang
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Wei Dang
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Wei Dang
- National Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Wei Dang
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Shuyu Xin
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Shuyu Xin
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Shuyu Xin
- National Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Shuyu Xin
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Sijing Long
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Sijing Long
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Sijing Long
- National Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Sijing Long
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Wentao Zhang
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Wentao Zhang
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Wentao Zhang
- National Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Wentao Zhang
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Pengfei Cao
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Pengfei Cao
- National Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Pengfei Cao
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- Jianhong Lu
- Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
- Jianhong Lu
- Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China
- Jianhong Lu
- National Healthcare Commission (NHC) Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, China
- Jianhong Lu
- China-Africa Research Center of Infectious Diseases, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fcell.2021.722020
- Journal volume & issue
-
Vol. 9
Abstract
Extracellular vesicles (EVs), consisting of exosomes, micro-vesicles, and other vesicles, mainly originate from the multi-vesicular body (MVB) pathway or plasma membrane. EVs are increasingly recognized as a tool to mediate the intercellular communication and are closely related to human health. Viral infection is associated with various diseases, including respiratory diseases, neurological diseases, and cancers. Accumulating studies have shown that viruses could modulate their infection ability and pathogenicity through regulating the component and function of EVs. Non-coding RNA (ncRNA) molecules are often targets of viruses and also serve as the main functional cargo of virus-related EVs, which have an important role in the epigenetic regulation of target cells. In this review, we summarize the research progress of EVs under the regulation of viruses, highlighting the content alteration and function of virus-regulated EVs, emphasizing their isolation methods in the context of virus infection, and potential antiviral strategies based on their use. This review would promote the understanding of the viral pathogenesis and the development of antiviral research.
Keywords