Scientific Reports (Nov 2024)

Tensor-valued diffusion MRI detects brain microstructural abnormalities in HIV infected individuals with cognitive impairment

  • Md Nasir Uddin,
  • Meera V. Singh,
  • Abrar Faiyaz,
  • Filip Szczepankiewicz,
  • Markus Nilsson,
  • Zachary D. Boodoo,
  • Karli R. Sutton,
  • Madalina E. Tivarus,
  • Jianhui Zhong,
  • Lu Wang,
  • Xing Qiu,
  • Miriam T. Weber,
  • Giovanni Schifitto

DOI
https://doi.org/10.1038/s41598-024-80372-8
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 13

Abstract

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Abstract Despite advancements, the prevalence of HIV-associated neurocognitive impairment remains at approximately 40%, attributed to factors like pre-cART (combination antiretroviral therapy) irreversible brain injury. People with HIV (PWH) treated with cART do not show significant neurocognitive changes over relatively short follow-up periods. However, quantitative neuroimaging may be able to detect ongoing subtle microstructural changes. In this study, we hypothesized that tensor-valued diffusion encoding metrics would provide greater sensitivity than conventional diffusion tensor imaging (DTI) metrics in detecting HIV-associated brain microstructural injury. We further hypothesized that tensor-valued metrics would exhibit stronger associations with blood markers of neuronal and glial injury, such as neurofilament light chain (NFL) and glial fibrillary acidic protein (GFAP), as well as with cognitive performance. Using MRI at 3T, 24 PWH and 31 healthy controls underwent cross-sectional examination. The results revealed significant variations in tensor-valued diffusion encoding metrics across white matter regions, with associations observed between these metrics, cognitive performance, NFL and GFAP. Moreover, a significant interaction between HIV status and imaging metrics in gray and white matter was observed, particularly impacting total cognitive scores. Of interest, DTI metrics were less likely to be associated with HIV status than tensor-valued diffusion metrics. These findings suggest that tensor-valued diffusion encoding metrics offer heightened sensitivity in detecting subtle changes associated with axonal injury in HIV infection. Longitudinal studies are needed to further evaluate responsiveness of tensor-valued diffusion b-tensor encoding metrics in the contest HIV-associate mild chronic neuroinflammation.

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