Nature Communications (Oct 2017)

Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

  • Anna Tchenio,
  • Salvatore Lecca,
  • Kristina Valentinova,
  • Manuel Mameli

DOI
https://doi.org/10.1038/s41467-017-01192-1
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 8

Abstract

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Early-life stress primes depression in adulthood. This study shows that early maternal separation leads to lateral habenula (LHb) hyperactivity and causes depressive-like phenotypes, the latter being reversible when LHb hyperactivity is reduced chemogenetically or through deep-brain stimulation.