Nature Communications (Oct 2019)
The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos
- Jelena Erceg,
- Jumana AlHaj Abed,
- Anton Goloborodko,
- Bryan R. Lajoie,
- Geoffrey Fudenberg,
- Nezar Abdennur,
- Maxim Imakaev,
- Ruth B. McCole,
- Son C. Nguyen,
- Wren Saylor,
- Eric F. Joyce,
- T. Niroshini Senaratne,
- Mohammed A. Hannan,
- Guy Nir,
- Job Dekker,
- Leonid A. Mirny,
- C.-ting Wu
Affiliations
- Jelena Erceg
- Department of Genetics, Harvard Medical School
- Jumana AlHaj Abed
- Department of Genetics, Harvard Medical School
- Anton Goloborodko
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
- Bryan R. Lajoie
- Howard Hughes Medical Institute and Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
- Geoffrey Fudenberg
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
- Nezar Abdennur
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
- Maxim Imakaev
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
- Ruth B. McCole
- Department of Genetics, Harvard Medical School
- Son C. Nguyen
- Department of Genetics, Harvard Medical School
- Wren Saylor
- Department of Genetics, Harvard Medical School
- Eric F. Joyce
- Department of Genetics, Harvard Medical School
- T. Niroshini Senaratne
- Department of Genetics, Harvard Medical School
- Mohammed A. Hannan
- Department of Genetics, Harvard Medical School
- Guy Nir
- Department of Genetics, Harvard Medical School
- Job Dekker
- Howard Hughes Medical Institute and Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
- Leonid A. Mirny
- Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT)
- C.-ting Wu
- Department of Genetics, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-019-12211-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Homologs are paired in Drosophila somatic cells from embryogenesis to adulthood. Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation and demonstrate its application to mammalian embryos.
