Nature Communications (Jan 2023)
SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19
- Oksana V. Stanevich,
- Evgeniia I. Alekseeva,
- Maria Sergeeva,
- Artem V. Fadeev,
- Kseniya S. Komissarova,
- Anna A. Ivanova,
- Tamara S. Simakova,
- Kirill A. Vasilyev,
- Anna-Polina Shurygina,
- Marina A. Stukova,
- Ksenia R. Safina,
- Elena R. Nabieva,
- Sofya K. Garushyants,
- Galya V. Klink,
- Evgeny A. Bakin,
- Jullia V. Zabutova,
- Anastasia N. Kholodnaia,
- Olga V. Lukina,
- Irina A. Skorokhod,
- Viktoria V. Ryabchikova,
- Nadezhda V. Medvedeva,
- Dmitry A. Lioznov,
- Daria M. Danilenko,
- Dmitriy M. Chudakov,
- Andrey B. Komissarov,
- Georgii A. Bazykin
Affiliations
- Oksana V. Stanevich
- Smorodintsev Research Institute of Influenza
- Evgeniia I. Alekseeva
- Skolkovo Institute of Science and Technology (Skoltech)
- Maria Sergeeva
- Smorodintsev Research Institute of Influenza
- Artem V. Fadeev
- Smorodintsev Research Institute of Influenza
- Kseniya S. Komissarova
- Smorodintsev Research Institute of Influenza
- Anna A. Ivanova
- Smorodintsev Research Institute of Influenza
- Tamara S. Simakova
- Parseq Lab Co. Ltd
- Kirill A. Vasilyev
- Smorodintsev Research Institute of Influenza
- Anna-Polina Shurygina
- Smorodintsev Research Institute of Influenza
- Marina A. Stukova
- Smorodintsev Research Institute of Influenza
- Ksenia R. Safina
- Skolkovo Institute of Science and Technology (Skoltech)
- Elena R. Nabieva
- A.A. Kharkevich Institute for Information Transmission Problems of the Russian Academy of Sciences
- Sofya K. Garushyants
- A.A. Kharkevich Institute for Information Transmission Problems of the Russian Academy of Sciences
- Galya V. Klink
- A.A. Kharkevich Institute for Information Transmission Problems of the Russian Academy of Sciences
- Evgeny A. Bakin
- First Pavlov State Medical University
- Jullia V. Zabutova
- City Hospital 31
- Anastasia N. Kholodnaia
- First Pavlov State Medical University
- Olga V. Lukina
- First Pavlov State Medical University
- Irina A. Skorokhod
- City Hospital 31
- Viktoria V. Ryabchikova
- City Hospital 31
- Nadezhda V. Medvedeva
- City Hospital 31
- Dmitry A. Lioznov
- Smorodintsev Research Institute of Influenza
- Daria M. Danilenko
- Smorodintsev Research Institute of Influenza
- Dmitriy M. Chudakov
- Skolkovo Institute of Science and Technology (Skoltech)
- Andrey B. Komissarov
- Smorodintsev Research Institute of Influenza
- Georgii A. Bazykin
- Skolkovo Institute of Science and Technology (Skoltech)
- DOI
- https://doi.org/10.1038/s41467-022-34033-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 11
Abstract
Here, the authors report accelerated intrahost evolution of SARS-CoV-2 in an immunocompromised patient with non-Hodgkin’s lymphoma with 318 days long COVID-19, and show that changes in the viral genome resulted in escape from T cellular immune response.
