Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies

Ruofan Li; Michael Mor; Bingting Ma; Alex E. Clark; Joel Alter; Michal Werbner; Jamie Casey Lee; Sandra L. Leibel; Aaron F. Carlin; Moshe Dessau; Meital Gal-Tanamy; Ben A. Croker; Ye Xiang; Natalia T. Freund

doi:10.1038/s42003-022-03739-5

Communications Biology (Aug 2022)

Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies

Ruofan Li,
Michael Mor,
Bingting Ma,
Alex E. Clark,
Joel Alter,
Michal Werbner,
Jamie Casey Lee,
Sandra L. Leibel,
Aaron F. Carlin,
Moshe Dessau,
Meital Gal-Tanamy,
Ben A. Croker,
Ye Xiang,
Natalia T. Freund

Affiliations

Ruofan Li: Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Center for Infectious Disease Research, School of Medicine, Tsinghua University
Michael Mor: Department for Microbiology and Clinical Immunology, Faculty of Medicine, Tel Aviv University
Bingting Ma: Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Center for Infectious Disease Research, School of Medicine, Tsinghua University
Alex E. Clark: Department of Medicine, University of California San Diego
Joel Alter: The Laboratory of Structural Biology of Infectious Diseases, Azrieli Faculty of Medicine, Bar Ilan University
Michal Werbner: Molecular Virology Lab, Azrieli Faculty of Medicine, Bar Ilan University
Jamie Casey Lee: Department of Pediatrics, School of Medicine, UC San Diego
Sandra L. Leibel: Department of Pediatrics, School of Medicine, UC San Diego
Aaron F. Carlin: Department of Medicine, University of California San Diego
Moshe Dessau: The Laboratory of Structural Biology of Infectious Diseases, Azrieli Faculty of Medicine, Bar Ilan University
Meital Gal-Tanamy: Molecular Virology Lab, Azrieli Faculty of Medicine, Bar Ilan University
Ben A. Croker: Department of Pediatrics, School of Medicine, UC San Diego
Ye Xiang: Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Center for Infectious Disease Research, School of Medicine, Tsinghua University
Natalia T. Freund: Department for Microbiology and Clinical Immunology, Faculty of Medicine, Tel Aviv University

DOI: https://doi.org/10.1038/s42003-022-03739-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

Read online

The neutralization of SARS-CoV-2 and variants of concern by nine monoclonal antibodies (mAb) isolated from convalescent donors infected with the Wuhan-Hu-1 strain alongside structural characterization of two of the mAbs in complex with the RBD and spike are presented.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal