Decreased expression of MUC2 due to a decrease in the expression of lectins and apoptotic defects in colitis patients

Abstract

Introduction: The involvement of mucin, lectin, and apoptosis in colitis is still unclear. This study aimed to investigate changes in MUC2 expression, inflammation, and changes in lectin expression in colitis patients. Methods: A total of 17 patients were divided into two groups including 11 hemorrhoid patients as a control group and 6 colitis patients. MUC2 mutation analysis was carried out using immunofluorescent and FISH techniques. Assessment of caspase-3, Ki-67, NF-kB, and lectin expressions was also carried out by immunofluorescent technique then analyzed by confocal laser scanning microscope. Results: The MUC2, caspase-3, and lectin expressions were significantly lower in the colitis group than in the control group (p < 0.05). Conclusions: It was concluded that in colitis there was a change in MUC2 expression due to changes in lectins accompanied by apoptotic defects.conclusion Keywords: Mucin, Inflammation, Apoptosis, Lectin, Colon