Nature Communications (Aug 2019)

GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling

  • Shinji Matsumoto,
  • Taku Yamamichi,
  • Koei Shinzawa,
  • Yuuya Kasahara,
  • Satoshi Nojima,
  • Takahiro Kodama,
  • Satoshi Obika,
  • Tetsuo Takehara,
  • Eiichi Morii,
  • Hiroomi Okuyama,
  • Akira Kikuchi

DOI
https://doi.org/10.1038/s41467-019-11533-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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The mechanisms promoting hepatoblastoma (HB) progression through Wnt/β-catenin signaling are unclear. Here, the authors show that the Wnt/ β-catenin axis induces GREB1 expression and nuclear localization, and suppresses TGFβ pathway, and propose GREB1 as a therapeutic target in HB.