The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates

• Jiaxin Yang,
• Yan Li,
• Shijin Wang,
• Huili Li,
• Lili Zhang,
• Haichen Zhang,
• Pei-Hui Wang,
• Xiangyu Zheng,
• Xiao-Fang Yu,
• Wei Wei

Affiliations

Jiaxin Yang

Institute of Virology and AIDS Research, First Hospital, Jilin University

Yan Li

Institute of Virology and AIDS Research, First Hospital, Jilin University

Shijin Wang

Institute of Virology and AIDS Research, First Hospital, Jilin University

Huili Li

Institute of Virology and AIDS Research, First Hospital, Jilin University

Lili Zhang

Institute of Virology and AIDS Research, First Hospital, Jilin University

Haichen Zhang

Department of Neurology and Neuroscience Center, First Hospital, Jilin University

Pei-Hui Wang

Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University

Xiangyu Zheng

Department of Neurology and Neuroscience Center, First Hospital, Jilin University

Xiao-Fang Yu

Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine

Wei Wei

Institute of Virology and AIDS Research, First Hospital, Jilin University