Nature Communications (Jul 2017)
Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia
- Gero Knittel,
- Tim Rehkämper,
- Darya Korovkina,
- Paul Liedgens,
- Christian Fritz,
- Alessandro Torgovnick,
- Yussor Al-Baldawi,
- Mona Al-Maarri,
- Yupeng Cun,
- Oleg Fedorchenko,
- Arina Riabinska,
- Filippo Beleggia,
- Phuong-Hien Nguyen,
- F. Thomas Wunderlich,
- Monika Ortmann,
- Manuel Montesinos-Rongen,
- Eugen Tausch,
- Stephan Stilgenbauer,
- Lukas P. Frenzel,
- Marco Herling,
- Carmen Herling,
- Jasmin Bahlo,
- Michael Hallek,
- Martin Peifer,
- Reinhard Buettner,
- Thorsten Persigehl,
- H. Christian Reinhardt
Affiliations
- Gero Knittel
- Clinic I of Internal Medicine, University Hospital of Cologne
- Tim Rehkämper
- Clinic I of Internal Medicine, University Hospital of Cologne
- Darya Korovkina
- Clinic I of Internal Medicine, University Hospital of Cologne
- Paul Liedgens
- Clinic I of Internal Medicine, University Hospital of Cologne
- Christian Fritz
- Clinic I of Internal Medicine, University Hospital of Cologne
- Alessandro Torgovnick
- Clinic I of Internal Medicine, University Hospital of Cologne
- Yussor Al-Baldawi
- Department of Radiology, Medical Faculty, University Hospital of Cologne
- Mona Al-Maarri
- Max-Planck-Institute for Metabolism Research
- Yupeng Cun
- Department of Translational Genomics, University of Cologne
- Oleg Fedorchenko
- Clinic I of Internal Medicine, University Hospital of Cologne
- Arina Riabinska
- Clinic I of Internal Medicine, University Hospital of Cologne
- Filippo Beleggia
- Clinic I of Internal Medicine, University Hospital of Cologne
- Phuong-Hien Nguyen
- Clinic I of Internal Medicine, University Hospital of Cologne
- F. Thomas Wunderlich
- Max-Planck-Institute for Metabolism Research
- Monika Ortmann
- Institute of Pathology, University Hospital of Cologne
- Manuel Montesinos-Rongen
- Institute of Neuropathology, University Hospital of Cologne
- Eugen Tausch
- Department of Internal Medicine III, Ulm University
- Stephan Stilgenbauer
- Department of Internal Medicine III, Ulm University
- Lukas P. Frenzel
- Clinic I of Internal Medicine, University Hospital of Cologne
- Marco Herling
- Clinic I of Internal Medicine, University Hospital of Cologne
- Carmen Herling
- Clinic I of Internal Medicine, University Hospital of Cologne
- Jasmin Bahlo
- Clinic I of Internal Medicine, University Hospital of Cologne
- Michael Hallek
- Clinic I of Internal Medicine, University Hospital of Cologne
- Martin Peifer
- Department of Translational Genomics, University of Cologne
- Reinhard Buettner
- Center of Integrated Oncology (CIO), University Hospital of Cologne
- Thorsten Persigehl
- Department of Radiology, Medical Faculty, University Hospital of Cologne
- H. Christian Reinhardt
- Clinic I of Internal Medicine, University Hospital of Cologne
- DOI
- https://doi.org/10.1038/s41467-017-00210-6
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
ATM and TP53 mutations are associated with poor prognosis in chronic lymphocytic leukaemia (CLL). Here the authors generate mouse models of Tp53- and Atm-defective CLL mimicking the high-risk form of human disease and show that Atm-deficient CLL is sensitive to PARP1 inhibition.
