Rare variants lowering the levels of coagulation factor X are protective against ischemic heart disease

• Elvezia Maria Paraboschi,
• Amit Vikram Khera,
• Piera Angelica Merlini,
• Laura Gigante,
• Flora Peyvandi,
• Mark Chaffin,
• Marzia Menegatti,
• Fabiana Busti,
• Domenico Girelli,
• Nicola Martinelli,
• Oliviero Olivieri,
• Sekar Kathiresan,
• Diego Ardissino,
• Rosanna Asselta,
• Stefano Duga

Affiliations

Elvezia Maria Paraboschi

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy;Humanitas Clinical and Research Center, Rozzano, Italy

Amit Vikram Khera

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;Department of Medicine, Massachusetts General Hospital, Cardiology Division, Harvard Medical School, Boston, MA, USA;Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA

Piera Angelica Merlini

Division of Cardiology, Azienda Ospedaliera Ospedale Niguarda Cà Granda, Milan, Italy

Laura Gigante

Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy

Flora Peyvandi

Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Luigi Villa Foundation, Milan, Italy;Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy

Mark Chaffin

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;Department of Medicine, Massachusetts General Hospital, Cardiology Division, Harvard Medical School, Boston, MA, USA;Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA

Marzia Menegatti

Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Luigi Villa Foundation, Milan, Italy

Fabiana Busti

Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy

Domenico Girelli

Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy

Nicola Martinelli

Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy

Oliviero Olivieri

Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy

Sekar Kathiresan

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;Department of Medicine, Massachusetts General Hospital, Cardiology Division, Harvard Medical School, Boston, MA, USA;Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA

Diego Ardissino

Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy

Rosanna Asselta

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy;Humanitas Clinical and Research Center, Rozzano, Italy

Stefano Duga

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy;Humanitas Clinical and Research Center, Rozzano, Italy