BMJ Open Respiratory Research (Aug 2024)
Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis
- Sibylle Koletzko,
- Jordi Sunyer,
- Liesbeth Duijts,
- Henrique Barros,
- Steve Turner,
- Jolanda M A Boer,
- Ville Peltola,
- Geertje W Dalmeijer,
- Mads Melbye,
- Johnny Ludvigsson,
- Ulrike Gehring,
- Marie Standl,
- Anna Bergstrom,
- Andrea von Berg,
- Guillermo Fernandez-Tardon,
- Hazel M Inskip,
- Judith Garcia-Aymerich,
- Tamara Schikowski,
- Graham Devereux,
- Berthold Koletzko,
- Claudia E Kuehni,
- Hanna Lagström,
- Veit Grote,
- Tanja G M Vrijkotte,
- John Mehegan,
- Virissa Lenters,
- Isabella Annesi-Maesano,
- Ferran Ballester,
- Peter Bager,
- Katharine C Pike,
- Cecily Kelleher,
- Carel Thijs,
- Monique Mommers,
- Sandra Ekström,
- Klaus Bønnelykke,
- Maties Torrent,
- Margreet W Harskamp-van Ginkel,
- Mikel Subiza-Pérez,
- Åshild Faresjö,
- Marianne Eijkemans,
- Anders Ulrik Eliasen,
- Nour Baïz,
- Ana Cristina Santos,
- Sara M Mensink-Bout,
- Claudia Flexeder,
- Merete Åse Eggesbø,
- Mónica López-Vicente,
- Gunda Herberth,
- Eva S L Pedersen,
- Maria Jansen,
- Cornelis K van der Ent
Affiliations
- Sibylle Koletzko
- Department of Pediatrics, Gastroenterology and Nutrition, University of Warmia and Mazury in Olsztyn School of Medicine, Olsztyn, Poland
- Jordi Sunyer
- ISGlobal, Barcelona, Spain
- Liesbeth Duijts
- The Generation R Study Group, Erasmus Medical Center, Rotterdam, Netherlands
- Henrique Barros
- Instituto de Saúde Pública da Universidade do Porto, UP EPIUnit, Porto, Portugal
- Steve Turner
- Women and Children’s Division, NHS Grampian, Aberdeen, UK
- Jolanda M A Boer
- National Institute for Public Health and the Environment, Bilthoven, Netherlands
- Ville Peltola
- Department of Paediatrics and Adolescent Medicine, TYKS Turku University Hospital, Turku, Finland
- Geertje W Dalmeijer
- Julius Center for Health Sciences and Primary Care, Utrecht, Netherlands
- Mads Melbye
- K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway
- Johnny Ludvigsson
- Division of Pediatrics, Department of Biomedical and Clinical Sciences (BKV), Medical Faculty, Crown Princess Victoria Children`s Hospital, Linköping University Hospital, Linköping, Sweden
- Ulrike Gehring
- Utrecht University Institute for Risk Assessment Sciences, Utrecht, Netherlands
- Marie Standl
- German Center for Lung Research, Giessen, Germany
- Anna Bergstrom
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Andrea von Berg
- Research Institute, Department of Pediatrics, Marien-Hospital Wesel gGmbH, Wesel, Germany
- Guillermo Fernandez-Tardon
- Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), University of Oviedo, CIBERESP, Madrid, Spain
- Hazel M Inskip
- MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK
- Judith Garcia-Aymerich
- Non-Communicable Diseases and Environment Research Programme, Barcelona Institute for Global Health, Barcelona, Spain
- Tamara Schikowski
- Department of Epidemiology, IUF Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany
- Graham Devereux
- Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK
- Berthold Koletzko
- Department of Pediatrics, Munich University Hospital Dr von Hauner Children`s Hospital, Munchen, Germany
- Claudia E Kuehni
- Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
- Hanna Lagström
- Department of Public Health and Centre for Population Health Research, University of Turku, Turku, Finland
- Veit Grote
- Department of Pediatrics, Munich University Hospital Dr von Hauner Children`s Hospital, Munchen, Germany
- Tanja G M Vrijkotte
- Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC Locatie Meibergdreef, Amsterdam, Netherlands
- John Mehegan
- UCD School of Public Health, Physiotherapy and Sports Science, College of Health and Agricultural Sciences, University College Dublin, Dublin, Ireland
- Virissa Lenters
- Julius Center for Health Sciences and Primary Care, Utrecht, Netherlands
- Isabella Annesi-Maesano
- Institute Desbrest of Epidemiology and Public Health, University of Montpellier and INSERM, Montpellier, France
- Ferran Ballester
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
- Peter Bager
- Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
- Katharine C Pike
- Bristol Royal Hospital for Children, Bristol, UK
- Cecily Kelleher
- UCD School of Public Health, Physiotherapy and Sports Science, College of Health and Agricultural Sciences, University College Dublin, Dublin, Ireland
- Carel Thijs
- Maastricht University Care and Public Health Research Institute, Maastricht, Netherlands
- Monique Mommers
- Maastricht University Care and Public Health Research Institute, Maastricht, Netherlands
- Sandra Ekström
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Klaus Bønnelykke
- Copenhagen University Hospital, Gentofte, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen, Denmark
- Maties Torrent
- Àrea de Salut de Menorca, Menorca, Spain
- Margreet W Harskamp-van Ginkel
- Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC Locatie Meibergdreef, Amsterdam, Netherlands
- Mikel Subiza-Pérez
- Group of Environmental Epidemiology and Child Development, Biodonostia Health Research Institute, Donostia-san Sebastian, Spain
- Åshild Faresjö
- Department of Health, Medicine and Caring Sciences; Public Health, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden
- Marianne Eijkemans
- Department of Pediatrics, Catharina Ziekenhuis, Eindhoven, Netherlands
- Anders Ulrik Eliasen
- Copenhagen University Hospital, Gentofte, Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen, Denmark
- Nour Baïz
- Institute Desbrest of Epidemiology and Public Health, University of Montpellier and INSERM, Montpellier, France
- Ana Cristina Santos
- Instituto de Saúde Pública da Universidade do Porto, UP EPIUnit, Porto, Portugal
- Sara M Mensink-Bout
- The Generation R Study Group, Erasmus Medical Center, Rotterdam, Netherlands
- Claudia Flexeder
- Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munchen, Germany
- Merete Åse Eggesbø
- Department of Environmental Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
- Mónica López-Vicente
- ISGlobal, Barcelona, Spain
- Gunda Herberth
- Department of Environmental Immunology, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Germany
- Eva S L Pedersen
- Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
- Maria Jansen
- Public Health Services, Academic Collaborative Centre for Public Health Limburg, Heerlen, Netherlands
- Cornelis K van der Ent
- Department of Paediatric Pulmonology, Wilhelmina Children`s Hospital University Medical Centre, Utrecht, Netherlands
- DOI
- https://doi.org/10.1136/bmjresp-2023-001630
- Journal volume & issue
-
Vol. 11,
no. 1
Abstract
Objectives To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study.Design Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined.Setting Children aged 0–18 years from 26 European birth cohorts.Participants 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood.Main outcome measure Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6–18 years.Results Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3–5 years was not associated with asthma at age 6–18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results.Conclusions Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.
