Revista Cubana de Investigaciones Biomédicas (Jun 1997)
Comparación del efecto hipocolesterolémico de la colestina con la colestiramina
Abstract
Se comparó el efecto hipocolesterolémico de la colestiramina con la colestina, 2 fármacos de similar mecanismo de acción, en conejos Nueva Zelandia que recibieron estos productos incorporados al pienso en una dosis del 2 % durante 45 días. Al término del estudio se encontró en los grupos de animales que recibieron la colestiramina y la colestina una disminución significativa (p The hypocholesteremic effect of cholestyramine was compared with that of cholestene, 2 drugs of similar action mechanism, in rabbits from New Zealand that were administered a 2 % dose of these products through the feed during 45 days. At the end of the study, a significant reduction (p < 0,01) of the serum cholesterol concentrations was found in the group of animals that received cholestyramine and cholestene compared with the pretreatment levels and with the control group. The serum cholesterol reduction obtained with both drugs were of 35,5 and 36, respectively. No considerable changes were observed in the rest of the lipidic variables. The results show that the cholesteremic effect of cholestene is similar to that of cholestyramine.
