Nature Communications (Aug 2021)
A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration
- Andrea Raso,
- Ellen Dirkx,
- Vasco Sampaio-Pinto,
- Hamid el Azzouzi,
- Ryan J. Cubero,
- Daniel W. Sorensen,
- Lara Ottaviani,
- Servé Olieslagers,
- Manon M. Huibers,
- Roel de Weger,
- Sailay Siddiqi,
- Silvia Moimas,
- Consuelo Torrini,
- Lorena Zentillin,
- Luca Braga,
- Diana S. Nascimento,
- Paula A. da Costa Martins,
- Jop H. van Berlo,
- Serena Zacchigna,
- Mauro Giacca,
- Leon J. De Windt
Affiliations
- Andrea Raso
- Department of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University
- Ellen Dirkx
- Department of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University
- Vasco Sampaio-Pinto
- Department of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University
- Hamid el Azzouzi
- Department of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University
- Ryan J. Cubero
- The Abdus Salam International Centre for Theoretical Physics
- Daniel W. Sorensen
- Stem Cell Institute and Lillehei Heart Institute, Department of Medicine, University of Minnesota
- Lara Ottaviani
- Department of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University
- Servé Olieslagers
- Department of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University
- Manon M. Huibers
- Department of Pathology, University Medical Center Utrecht
- Roel de Weger
- Department of Pathology, University Medical Center Utrecht
- Sailay Siddiqi
- Department of Cardiothoracic Surgery, Radboud University Medical Center
- Silvia Moimas
- International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Consuelo Torrini
- International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Lorena Zentillin
- International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Luca Braga
- International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Diana S. Nascimento
- i3S - Instituto de Investigação e Inovação em Saúde, INEB - Instituto Nacional de Engenharia Biomédica, ICBAS - Instituto de Ciências Biomédicas de Abel Salazar, University of Porto
- Paula A. da Costa Martins
- Department of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University
- Jop H. van Berlo
- Stem Cell Institute and Lillehei Heart Institute, Department of Medicine, University of Minnesota
- Serena Zacchigna
- Department of Cardiothoracic Surgery, Radboud University Medical Center
- Mauro Giacca
- International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Leon J. De Windt
- Department of Molecular Genetics, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University
- DOI
- https://doi.org/10.1038/s41467-021-25211-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Myocardial regeneration and proliferation of heart muscle cells is limited to a short period after birth early postnatal life, after which heart muscle cells can only grow in size and not in number. Here, the authors identified that the expression level of an endogenous microRNA cluster in heart muscle promotes the passage of the proliferative state to adult heart growth, and modulating the expression of this cluster can stimulate heart regeneration after myocardial infarction.
