Wellcome Open Research (Sep 2019)

Expert voices and equal partnerships: establishing Controlled Human Infection Models (CHIMs) in Vietnam [version 1; peer review: 3 approved]

  • Evelyne Kestelyn,
  • Chi Le Phuong,
  • Jennifer Ilo Van Nuil,
  • Hoai Tam Dong Thi,
  • Nguyet Minh Nguyen,
  • Trung Dinh The,
  • Mary Chambers,
  • Cameron P. Simmons,
  • Toan Nguyen Trong,
  • Dung Nguyen The,
  • Le Truc Phuong,
  • Dung Do Van,
  • Dung Duc Anh,
  • Vinh Chau Nguyen Van,
  • Stephen Baker,
  • Bridget Wills,
  • OUCRU Controlled Human Infection Models workshop and focus group participants

DOI
https://doi.org/10.12688/wellcomeopenres.15337.1
Journal volume & issue
Vol. 4

Abstract

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The number of controlled human infection models (CHIMs) conducted worldwide has increased considerably in recent years, although few have been conducted in low and middle-income countries (LMICs), where infectious diseases have the greatest burden. Recently Oxford University Clinical Research Unit (OUCRU) in Ho Chi Minh City (HCMC) started developing CHIM research proposals motivated by the need to develop a clearer and more grounded understanding of the issues surrounding the conduct of CHIMs in LMICs. To explore initial perceptions and barriers to conducting CHIMs in Vietnam, OUCRU researchers conducted a set of key stakeholder interviews early in 2018 and held a CHIM workshop in HCMC in March 2018. This paper summarizes the discussions from the workshop and outlines a way forward for conducting CHIMs in Vietnam.