Frontiers in Microbiology (Sep 2021)

Regulation and Evasion of Host Immune Response by African Swine Fever Virus

  • Lei Wu,
  • Bincai Yang,
  • Xu Yuan,
  • Jinxuan Hong,
  • Min Peng,
  • Ji-Long Chen,
  • Zhongbao Song

DOI
https://doi.org/10.3389/fmicb.2021.698001
Journal volume & issue
Vol. 12

Abstract

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African swine fever (ASF) is an acute lethal hemorrhagic viral disease in domestic pigs and wild boars; is widely epidemic in Africa, Europe, Asia, and Latin America; and poses a huge threat to the pig industry worldwide. ASF is caused by the infection of the ASF virus (ASFV), a cytoplasmic double-stranded DNA virus belonging to the Asfarviridae family. Here, we review how the virus regulates the host immune response and its mechanisms at different levels, including interferon modulation, inflammation, apoptosis, antigen presentation, and cellular immunity.

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