PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth

Ling Guo; Chunhong Cui; Jiaxin Wang; Jifan Yuan; Qingyang Yang; Ping Zhang; Wen Su; Ruolu Bao; Jingchao Ran; Chuanyue Wu

doi:10.1038/s41467-020-18753-6

Nature Communications (Oct 2020)

PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth

Ling Guo,
Chunhong Cui,
Jiaxin Wang,
Jifan Yuan,
Qingyang Yang,
Ping Zhang,
Wen Su,
Ruolu Bao,
Jingchao Ran,
Chuanyue Wu

Affiliations

Ling Guo: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and Technology
Chunhong Cui: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and Technology
Jiaxin Wang: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and Technology
Jifan Yuan: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and Technology
Qingyang Yang: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and Technology
Ping Zhang: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and Technology
Wen Su: Department of Pathology, Shenzhen University Health Science Center
Ruolu Bao: Department of Pathology, Shenzhen University Health Science Center
Jingchao Ran: Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies and Department of Biology, Southern University of Science and Technology
Chuanyue Wu: Department of Pathology, University of Pittsburgh School of Medicine

DOI: https://doi.org/10.1038/s41467-020-18753-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 20

Abstract

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Proline metabolism is crucial to tumor proliferation. Here, the authors show PINCH-1 deficiency inhibited proline synthesis by promoting mitochondrial fragmentation via DRP1, downregulating PYCR1 expression and reducing cell proliferation in vitro and in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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