Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

Nicholas Collins; Xiaodong Jiang; Ali Zaid; Bethany L. Macleod; Jane Li; Chang Ook Park; Ashraful Haque; Sammy Bedoui; William R. Heath; Scott N. Mueller; Thomas S. Kupper; Thomas Gebhardt; Francis R. Carbone

doi:10.1038/ncomms11514

Nature Communications (May 2016)

Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

Nicholas Collins,
Xiaodong Jiang,
Ali Zaid,
Bethany L. Macleod,
Jane Li,
Chang Ook Park,
Ashraful Haque,
Sammy Bedoui,
William R. Heath,
Scott N. Mueller,
Thomas S. Kupper,
Thomas Gebhardt,
Francis R. Carbone

Affiliations

Nicholas Collins: Department of Microbiology and Immunology; Peter Doherty Institute for Infection and Immunity, The University of Melbourne
Xiaodong Jiang: Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women’s Hospital, Harvard Medical School
Ali Zaid: Department of Microbiology and Immunology; Peter Doherty Institute for Infection and Immunity, The University of Melbourne
Bethany L. Macleod: Department of Microbiology and Immunology; Peter Doherty Institute for Infection and Immunity, The University of Melbourne
Jane Li: Department of Microbiology and Immunology; Peter Doherty Institute for Infection and Immunity, The University of Melbourne
Chang Ook Park: Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women’s Hospital, Harvard Medical School
Ashraful Haque: Malaria Immunology Laboratory, QIMR Berghofer Medical Research Institute and Australian Infectious Diseases Research Centre, The University of Queensland
Sammy Bedoui: Department of Microbiology and Immunology; Peter Doherty Institute for Infection and Immunity, The University of Melbourne
William R. Heath: Department of Microbiology and Immunology; Peter Doherty Institute for Infection and Immunity, The University of Melbourne
Scott N. Mueller: Department of Microbiology and Immunology; Peter Doherty Institute for Infection and Immunity, The University of Melbourne
Thomas S. Kupper: Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women’s Hospital, Harvard Medical School
Thomas Gebhardt: Department of Microbiology and Immunology; Peter Doherty Institute for Infection and Immunity, The University of Melbourne
Francis R. Carbone: Department of Microbiology and Immunology; Peter Doherty Institute for Infection and Immunity, The University of Melbourne

DOI: https://doi.org/10.1038/ncomms11514
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

Memory T cells are vital responders to skin inflammation, but cell localization and dynamics of exchange with the bloodstream are not clear. Here the authors use parabiosis and intravital microscopy to show that CD4+memory T cells equilibrate with the circulation and cluster around hair follicles in response to CCL5-dependent responses to viral infection or contact sensitization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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