Nature Communications (Aug 2019)

The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis

  • Mohamed Osama Ali Abdalla,
  • Tatsuro Yamamoto,
  • Kazumitsu Maehara,
  • Jumpei Nogami,
  • Yasuyuki Ohkawa,
  • Hisashi Miura,
  • Rawin Poonperm,
  • Ichiro Hiratani,
  • Hideki Nakayama,
  • Mitsuyoshi Nakao,
  • Noriko Saitoh

DOI
https://doi.org/10.1038/s41467-019-11378-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Long term estrogen deprivation can result in apoptosis in breast cancer cells. Here, the authors show that this apoptosis is induced by the long-range chromatin interaction of loci containing the ESR1 and FOXO 3 genes, resulting in FOXO 3-mediated apoptosis.