Genetic and phenotypic analysis of the causal relationship between aging and COVID-19

Kejun Ying; Ranran Zhai; Timothy V. Pyrkov; Anastasia V. Shindyapina; Marco Mariotti; Peter O. Fedichev; Xia Shen; Vadim N. Gladyshev

doi:10.1038/s43856-021-00033-z

Communications Medicine (Oct 2021)

Genetic and phenotypic analysis of the causal relationship between aging and COVID-19

Kejun Ying,
Ranran Zhai,
Timothy V. Pyrkov,
Anastasia V. Shindyapina,
Marco Mariotti,
Peter O. Fedichev,
Xia Shen,
Vadim N. Gladyshev

Affiliations

Kejun Ying: Biostatistics Group, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University
Ranran Zhai: Biostatistics Group, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University
Timothy V. Pyrkov: Gero LLC PTE
Anastasia V. Shindyapina: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Marco Mariotti: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Peter O. Fedichev: Gero LLC PTE
Xia Shen: Biostatistics Group, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University
Vadim N. Gladyshev: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/s43856-021-00033-z
Journal volume & issue: Vol. 1, no. 1
pp. 1 – 15

Abstract

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Ying et al. conduct a multi-instrument Mendelian randomization study looking at the link between aging and COVID-19 risk. They observe an association between genetic variation implicated in longevity and decreased risk of COVID-19 infection and hospitalization, with Notch signaling and immune system development loci found to be important in aging-related COVID-19 risk.

Published in Communications Medicine

ISSN: 2730-664X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/commsmed/

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