Frontiers in Cellular Neuroscience (Nov 2021)
General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism
- Jianchen Cui,
- Jianchen Cui,
- Jianchen Cui,
- Jianchen Cui,
- Jianchen Cui,
- Jiho Park,
- Xianshu Ju,
- Xianshu Ju,
- Xianshu Ju,
- Yulim Lee,
- Yulim Lee,
- Yulim Lee,
- Yulim Lee,
- Boohwi Hong,
- Boohwi Hong,
- Jeonghoon Ahn,
- Yoon Hee Kim,
- Yoon Hee Kim,
- Youngkwon Ko,
- Youngkwon Ko,
- Seok-Hwa Yoon,
- Seok-Hwa Yoon,
- Chaeseong Lim,
- Chaeseong Lim,
- Sun Yeul Lee,
- Sun Yeul Lee,
- Sung-Oh Huh,
- Jun Young Heo,
- Jun Young Heo,
- Jun Young Heo,
- Woosuk Chung,
- Woosuk Chung,
- Woosuk Chung,
- Woosuk Chung
Affiliations
- Jianchen Cui
- Department of Medical Science, Chungnam National University School of Medicine, Daejeon, South Korea
- Jianchen Cui
- Department of Biochemistry, Chungnam National University School of Medicine, Daejeon, South Korea
- Jianchen Cui
- Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon, South Korea
- Jianchen Cui
- Department of Anesthesiology, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China
- Jianchen Cui
- Brain Korea 21 FOUR Project for Medical Science, Chungnam National University, Daejeon, South Korea
- Jiho Park
- Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, South Korea
- Xianshu Ju
- Department of Medical Science, Chungnam National University School of Medicine, Daejeon, South Korea
- Xianshu Ju
- Department of Biochemistry, Chungnam National University School of Medicine, Daejeon, South Korea
- Xianshu Ju
- Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon, South Korea
- Yulim Lee
- Department of Medical Science, Chungnam National University School of Medicine, Daejeon, South Korea
- Yulim Lee
- Department of Biochemistry, Chungnam National University School of Medicine, Daejeon, South Korea
- Yulim Lee
- Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon, South Korea
- Yulim Lee
- Brain Korea 21 FOUR Project for Medical Science, Chungnam National University, Daejeon, South Korea
- Boohwi Hong
- Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, South Korea
- Boohwi Hong
- Department of Anesthesiology and Pain Medicine, Chungnam National University School of Medicine, Daejeon, South Korea
- Jeonghoon Ahn
- Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, South Korea
- Yoon Hee Kim
- Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, South Korea
- Yoon Hee Kim
- Department of Anesthesiology and Pain Medicine, Chungnam National University School of Medicine, Daejeon, South Korea
- Youngkwon Ko
- Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, South Korea
- Youngkwon Ko
- Department of Anesthesiology and Pain Medicine, Chungnam National University School of Medicine, Daejeon, South Korea
- Seok-Hwa Yoon
- Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, South Korea
- Seok-Hwa Yoon
- Department of Anesthesiology and Pain Medicine, Chungnam National University School of Medicine, Daejeon, South Korea
- Chaeseong Lim
- Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, South Korea
- Chaeseong Lim
- Department of Anesthesiology and Pain Medicine, Chungnam National University School of Medicine, Daejeon, South Korea
- Sun Yeul Lee
- Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, South Korea
- Sun Yeul Lee
- Department of Anesthesiology and Pain Medicine, Chungnam National University School of Medicine, Daejeon, South Korea
- Sung-Oh Huh
- Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University, Chuncheon, South Korea
- Jun Young Heo
- Department of Medical Science, Chungnam National University School of Medicine, Daejeon, South Korea
- Jun Young Heo
- Department of Biochemistry, Chungnam National University School of Medicine, Daejeon, South Korea
- Jun Young Heo
- Brain Korea 21 FOUR Project for Medical Science, Chungnam National University, Daejeon, South Korea
- Woosuk Chung
- Department of Medical Science, Chungnam National University School of Medicine, Daejeon, South Korea
- Woosuk Chung
- Brain Korea 21 FOUR Project for Medical Science, Chungnam National University, Daejeon, South Korea
- Woosuk Chung
- Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, South Korea
- Woosuk Chung
- Department of Anesthesiology and Pain Medicine, Chungnam National University School of Medicine, Daejeon, South Korea
- DOI
- https://doi.org/10.3389/fncel.2021.772047
- Journal volume & issue
-
Vol. 15
Abstract
Preclinical studies suggest that repeated exposure to anesthetics during a critical period of neurodevelopment induces long-term changes in synaptic transmission, plasticity, and behavior. Such changes are of great concern, as similar changes have also been identified in animal models of neurodevelopmental disorders (NDDs) such as autism. Because of overlapping synaptic changes, it is also possible that anesthetic exposures have a more significant effect in individuals diagnosed with NDDs. Thus, we evaluated the effects of early, multiple anesthetic exposures in BTBR mice, an inbred strain that displays autistic behavior. We discovered that three cycles of sevoflurane anesthesia (2.5%, 1 h) with 2-h intervals between each exposure in late postnatal BTBR mice did not aggravate, but instead improved pathophysiological mechanisms involved with autistic behavior. Sevoflurane exposures restored E/I balance (by increasing inhibitory synaptic transmission), and increased mitochondrial respiration and BDNF signaling in BTBR mice. Most importantly, such changes were associated with reduced autistic behavior in BTBR mice, as sociability was increased in the three-chamber test and repetitive behavior was reduced in the self-grooming test. Our results suggest that anesthetic exposures during neurodevelopment may affect individuals diagnosed with NDDs differently.
Keywords
- autism
- anesthesia
- BDNF (brain derived neurotrophic factor)
- BTBR
- E/I imbalance
- mitochondrial respiration
