The Effect of Co-activation of Antagonist Muscles on Motor Cortex Excitability: A Transcranial Magnetic Stimulation Study

Abstract

The effect of unilateral tonic muscle activity with and without co-activation of the antagonists on motor cortex excitability has been studied in seven right handed healthy volunteers. Contralateral motor evoked potentials (MEPs) were recorded from the first dorsal interosseous muscles of right hands in response to transcranial magnetic stimulation (TMS) during relax, isometric index finger abduction and antagonistic co-activation. The intracortical facilitation (ICF), short- and long-latency intracortical inhibition (SICI and LICI) were investigated by paired-pulse TMS. The unilateral tonic activation of the right hand facilitated MEPs in response to single-pulse TMS. The increase of MEP amplitudes was significantly greater during isometric index finger abduction compared to co-activation of antagonist muscles. During paired-pulse TMS with short interstimulus intervals, the SICI (interstimulus interval of 3 ms) was not influenced by the unilateral tonic activity while ICF (interstimulus interval of 13 ms) was suppressed. During paired-pulse TMS with longer interstimulus interval (100 ms) the LICI was not influenced during isometric index finger abduction while during antagonistic co-activation the LICI was significantly less pronounced. The decreased LICI is assumed to reflect mechanisms underlying the co-activation of antagonists.

Keywords

• Transcranial magnetic stimulation
• Motor evoked potential
• Intracortical facilitation
• Short-latency intracortical inhibition
• Long-latency intracortical inhibition
• Co-activation