Nature Communications (May 2020)

hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma

  • Pauline Herviou,
  • Morgane Le Bras,
  • Leïla Dumas,
  • Corinne Hieblot,
  • Julia Gilhodes,
  • Gianluca Cioci,
  • Jean-Philippe Hugnot,
  • Alfred Ameadan,
  • François Guillonneau,
  • Erik Dassi,
  • Anne Cammas,
  • Stefania Millevoi

DOI
https://doi.org/10.1038/s41467-020-16168-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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RNA G-quadruplexes (RG4s) have been functionally linked to cancer gene expression. Here, Herviou, Le Bras et al. have identified the protein machinery modulating RG4s and reveal the role and mechanism of hnRNP H/F and DHX36 in RG4-mediated translational regulation affecting cancer treatment in glioblastoma.