Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease

Moustafa Algamal; Alyssa N. Russ; Morgan R. Miller; Steven S. Hou; Megi Maci; Leon P. Munting; Qiuchen Zhao; Dmitry Gerashchenko; Brian J. Bacskai; Ksenia V. Kastanenka

doi:10.1038/s42003-022-04268-x

Communications Biology (Dec 2022)

Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease

Moustafa Algamal,
Alyssa N. Russ,
Morgan R. Miller,
Steven S. Hou,
Megi Maci,
Leon P. Munting,
Qiuchen Zhao,
Dmitry Gerashchenko,
Brian J. Bacskai,
Ksenia V. Kastanenka

Affiliations

Moustafa Algamal: Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School
Alyssa N. Russ: Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School
Morgan R. Miller: Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School
Steven S. Hou: Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School
Megi Maci: Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School
Leon P. Munting: Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School
Qiuchen Zhao: Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School
Dmitry Gerashchenko: Harvard Medical School/VA Boston Healthcare System
Brian J. Bacskai: Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School
Ksenia V. Kastanenka: Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/s42003-022-04268-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 9

Abstract

Read online

Interneuron-specific lines reveal that somatostatin interneurons are hyperactive whereas pyramidal neurons and PV interneurons are ‘hypoactive’ in the APP/PS1 mouse model of Alzheimer’s Disease.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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