Pretreatment of diabetic aged rats with combination of ginsenoside-Mc1 and silibinin protects liver from ischemia-reperfusion injury through an AMPK-dependent mechanism

Wang Hao; Zhu Jiali; Jia Zhe; Lu Sucai

doi:10.1515/tjb-2021-0010

Türk Biyokimya Dergisi (Jun 2021)

Pretreatment of diabetic aged rats with combination of ginsenoside-Mc1 and silibinin protects liver from ischemia-reperfusion injury through an AMPK-dependent mechanism

Wang Hao,
Zhu Jiali,
Jia Zhe,
Lu Sucai

Affiliations

Wang Hao: Gastroenterology Department, Affiliated Hospital of Hebei University, Baoding, Hebei, China
Zhu Jiali: Gastroenterology Department, Affiliated Hospital of Hebei University, Baoding, Hebei, China
Jia Zhe: Gastroenterology Department, Affiliated Hospital of Hebei University, Baoding, Hebei, China
Lu Sucai: Gastroenterology Department, Affiliated Hospital of Hebei University, Baoding, Hebei, China

DOI: https://doi.org/10.1515/tjb-2021-0010
Journal volume & issue: Vol. 47, no. 1
pp. 23 – 32

Abstract

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This study evaluated the protective efficacy of combination treatment with ginsenoside-Mc1 and silibinin against hepatic ischemia-reperfusion (IR) injury in diabetic-aged rats, and further explored AMPK’s role in this protection.

Published in Türk Biyokimya Dergisi

ISSN: 1303-829X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.degruyter.com/journal/key/tjb/html

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