CHROMATIN ACCESSIBILITY TO DNA MINOR GROOVE LIGANDS IN VITRO: ROLE OF LINKER HISTONES AND AMINO-TERMINAL DOMAINS OF OCT AMER HISTONES

Abstract

The processes of eukaryotic gene expression must be considered in the light of the intrinsically dynamic properties of chromatin, and, in particular, of the basic level of it which is the nucleosome. It is now clear that in the process of chromatin condensation two structures have a prominent role: the amino-terminal domains of the histone octamer and the linker histones (Hl, HS and the other isoforms). [...]