Nature Communications (Jan 2023)
Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity
- Yue Liu,
- Yue Yang,
- Chenying Xu,
- Jianxing Liu,
- Jiale Chen,
- Guoqing Li,
- Bin Huang,
- Yi Pan,
- Yanfeng Zhang,
- Qiong Wei,
- Stephen J. Pandol,
- Fangfang Zhang,
- Ling Li,
- Liang Jin
Affiliations
- Yue Liu
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University
- Yue Yang
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University
- Chenying Xu
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University
- Jianxing Liu
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University
- Jiale Chen
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University
- Guoqing Li
- Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University
- Bin Huang
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University
- Yi Pan
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University
- Yanfeng Zhang
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University
- Qiong Wei
- Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University
- Stephen J. Pandol
- Departments of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center
- Fangfang Zhang
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University
- Ling Li
- Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University
- Liang Jin
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University
- DOI
- https://doi.org/10.1038/s41467-023-35998-z
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
Pancreatic β-cell compensation is a major mechanism in delaying T2DM progression. Here, the authors show that circGlis3 levels are affected by QKI and FUS expression, and that increasing circGlis3 lengthens β-cell compensation via enhancing insulin secretion and reducing apoptosis.
