Nature Communications (Aug 2022)

Structural basis of transcriptional regulation by a nascent RNA element, HK022 putRNA

  • Seungha Hwang,
  • Paul Dominic B. Olinares,
  • Jimin Lee,
  • Jinwoo Kim,
  • Brian T. Chait,
  • Rodney A. King,
  • Jin Young Kang

DOI
https://doi.org/10.1038/s41467-022-32315-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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HK022 put is an RNA element that inhibits transcription termination without aids from protein factors. Here, authors solved cryo-EM structures of put-associated RNA polymerase and showed the structure of putRNA and its binding to the RNA polymerase.