Deep Brain Stimulation Mechanisms in Parkinson's Disease: Immediate and Long-Term Effects

Abstract

Deep brain stimulation (DBS) is a common therapy for managing Parkinson’s disease (PD) in clinical practice. However, a complete understanding of its mode of action is still needed. DBS is believed to work primarily through electrical and neurochemical pathways. Furthermore, DBS has other mechanisms of action. This review explores the fundamental concepts and applications of DBS in treating PD, including its mechanisms, clinical implications, and recent research.

Keywords

• basal ganglia
• beta oscillations
• deep brain stimulation
• neuroprotection
• neurotransmitters
• parkinson's disease