Structural basis of BAK activation in mitochondrial apoptosis initiation

Geetika Singh; Cristina D. Guibao; Jayaraman Seetharaman; Anup Aggarwal; Christy R. Grace; Dan E. McNamara; Sivaraja Vaithiyalingam; M. Brett Waddell; Tudor Moldoveanu

doi:10.1038/s41467-021-27851-y

Nature Communications (Jan 2022)

Structural basis of BAK activation in mitochondrial apoptosis initiation

Geetika Singh,
Cristina D. Guibao,
Jayaraman Seetharaman,
Anup Aggarwal,
Christy R. Grace,
Dan E. McNamara,
Sivaraja Vaithiyalingam,
M. Brett Waddell,
Tudor Moldoveanu

Affiliations

Geetika Singh: Department of Structural Biology, St. Jude Children’s Research Hospital
Cristina D. Guibao: Department of Structural Biology, St. Jude Children’s Research Hospital
Jayaraman Seetharaman: Department of Structural Biology, St. Jude Children’s Research Hospital
Anup Aggarwal: Department of Structural Biology, St. Jude Children’s Research Hospital
Christy R. Grace: Department of Structural Biology, St. Jude Children’s Research Hospital
Dan E. McNamara: Department of Structural Biology, St. Jude Children’s Research Hospital
Sivaraja Vaithiyalingam: Department of Structural Biology, St. Jude Children’s Research Hospital
M. Brett Waddell: Department of Structural Biology, St. Jude Children’s Research Hospital
Tudor Moldoveanu: Department of Structural Biology, St. Jude Children’s Research Hospital

DOI: https://doi.org/10.1038/s41467-021-27851-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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The authors show that the mechanism of BAK activation in mitochondrial apoptosis involves cooperation between direct activation by BH3-only protein BID and BAK autoactivation, providing a unifying basis for BAK triggering by BH3 ligands.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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