Cerium-Containing Mesoporous Bioactive Glasses (MBGs)-Derived Scaffolds with Drug Delivery Capability for Potential Tissue Engineering Applications

Irina Atkinson; Ana Maria Seciu-Grama; Simona Petrescu; Daniela Culita; Oana Catalina Mocioiu; Mariana Voicescu; Raul-Augustin Mitran; Daniel Lincu; Ana-Maria Prelipcean; Oana Craciunescu

doi:10.3390/pharmaceutics14061169

Pharmaceutics (May 2022)

Cerium-Containing Mesoporous Bioactive Glasses (MBGs)-Derived Scaffolds with Drug Delivery Capability for Potential Tissue Engineering Applications

Irina Atkinson,
Ana Maria Seciu-Grama,
Simona Petrescu,
Daniela Culita,
Oana Catalina Mocioiu,
Mariana Voicescu,
Raul-Augustin Mitran,
Daniel Lincu,
Ana-Maria Prelipcean,
Oana Craciunescu

Affiliations

Irina Atkinson: “Ilie Murgulescu” Institute of the Physical Chemistry of the Romanian Academy, 202, Spl. Independentei, 060021 Bucharest, Romania
Ana Maria Seciu-Grama: National Institute of Research and Development for Biological Sciences, 296, Spl. Independentei, 060031 Bucharest, Romania
Simona Petrescu: “Ilie Murgulescu” Institute of the Physical Chemistry of the Romanian Academy, 202, Spl. Independentei, 060021 Bucharest, Romania
Daniela Culita: “Ilie Murgulescu” Institute of the Physical Chemistry of the Romanian Academy, 202, Spl. Independentei, 060021 Bucharest, Romania
Oana Catalina Mocioiu: “Ilie Murgulescu” Institute of the Physical Chemistry of the Romanian Academy, 202, Spl. Independentei, 060021 Bucharest, Romania
Mariana Voicescu: “Ilie Murgulescu” Institute of the Physical Chemistry of the Romanian Academy, 202, Spl. Independentei, 060021 Bucharest, Romania
Raul-Augustin Mitran: “Ilie Murgulescu” Institute of the Physical Chemistry of the Romanian Academy, 202, Spl. Independentei, 060021 Bucharest, Romania
Daniel Lincu: “Ilie Murgulescu” Institute of the Physical Chemistry of the Romanian Academy, 202, Spl. Independentei, 060021 Bucharest, Romania
Ana-Maria Prelipcean: National Institute of Research and Development for Biological Sciences, 296, Spl. Independentei, 060031 Bucharest, Romania
Oana Craciunescu: National Institute of Research and Development for Biological Sciences, 296, Spl. Independentei, 060031 Bucharest, Romania

DOI: https://doi.org/10.3390/pharmaceutics14061169
Journal volume & issue: Vol. 14, no. 6
p. 1169

Abstract

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Finding innovative solutions to improve the lives of people affected by trauma, bone disease, or aging continues to be a challenge worldwide. Tissue engineering is the most rapidly growing area in the domain of biomaterials. Cerium-containing MBG-derived biomaterials scaffolds were synthesized using polymethyl methacrylate (PMMA) as a sacrificial template. The obtained scaffolds were characterized by X-ray powder diffraction (XRPD), infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The Ce4+/Ce3+ ratio in the scaffolds was estimated. In vitro testing revealed good cytocompatibility of the investigated scaffolds in mouse fibroblast cell line (NCTC clone L929). The results obtained regarding bioactivity, antibacterial activity, and controlled drug delivery functions recommend these scaffolds as potential candidates for bone tissue engineering applications.

Published in Pharmaceutics

ISSN: 1999-4923 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceutics/

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