Oxidative Stress Parameters in Predicting the Severity of Acute Pancreatitis

Abstract

Aim: The aim of our study was to investigate the importance of oxidative stress levels in the diagnosis and prognosis of acute pancreatitis.Materials and Methods: In total, 55 patients with acute pancreatitis and 47 healthy volunteers were included in the study. The study group was divided into three subgroups according to the computed tomography (CT) severity index. Group 1 consisted of patients with CT severity index score of 0-2, Group 2 consisted of patients with CT severity index of 3-6, and Group 3 consisted of patients with CT severity index 7-10. Total oxidant stress (TOS), total antioxidant stress (TAS), and oxidative stress index (OSI) were compared between study and control groups.Results: The mean age of the patients in the study group was significantly higher compared to the control group (p<0.001). No significant difference was found between groups in terms of sex (p=0.999). TOS (p<0.001), TAS (p<0.011), and OSI (p<0.001) levels were significantly higher in the study group compared to the control group. No significant difference was found between subgroups of the study group (Group 1-good prognosis, Group 2-moderate prognosis, Group 3-poor prognosis) with respect to TOS (p=0.844), TAS (p=0.600), and OSI (p=0.846) levels.Conclusion: Although our study does not support the use of oxidative stress parameters for the prediction of the severity and prognosis in patients with acute pancreatitis, additional and larger studies are warranted.

Keywords

• Pancreatitis
• oxidative stress
• prognosis
• diagnosis