Methylation-regulated decommissioning of multimeric PP2A complexes

Cheng-Guo Wu; Aiping Zheng; Li Jiang; Michael Rowse; Vitali Stanevich; Hui Chen; Yitong Li; Kenneth A. Satyshur; Benjamin Johnson; Ting-Jia Gu; Zuojia Liu; Yongna Xing

doi:10.1038/s41467-017-02405-3

Nature Communications (Dec 2017)

Methylation-regulated decommissioning of multimeric PP2A complexes

Cheng-Guo Wu,
Aiping Zheng,
Li Jiang,
Michael Rowse,
Vitali Stanevich,
Hui Chen,
Yitong Li,
Kenneth A. Satyshur,
Benjamin Johnson,
Ting-Jia Gu,
Zuojia Liu,
Yongna Xing

Affiliations

Cheng-Guo Wu: McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health
Aiping Zheng: McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health
Li Jiang: McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health
Michael Rowse: McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health
Vitali Stanevich: McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health
Hui Chen: McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health
Yitong Li: McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health
Kenneth A. Satyshur: McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health
Benjamin Johnson: McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health
Ting-Jia Gu: McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health
Zuojia Liu: McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health
Yongna Xing: McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health

DOI: https://doi.org/10.1038/s41467-017-02405-3
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Protein phosphatase 2A (PP2A) forms different holoenzymes but little is known about the disassembly of these important signalling complexes. Here the authors present the crystal structure of PP2A bound to TOR signaling pathway regulator (TIPRL) and give insights into the methylation-dependent disassembly of PP2A holenzymes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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