Nature Communications (Jul 2022)

Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth

  • Shao-Chin Wu,
  • Yuan-Ming Lo,
  • Jui-Hao Lee,
  • Chin-Yau Chen,
  • Tung-Wei Chen,
  • Hong-Wen Liu,
  • Wei-Nan Lian,
  • Kate Hua,
  • Chen-Chung Liao,
  • Wei-Ju Lin,
  • Chih-Yung Yang,
  • Chien-Yi Tung,
  • Chi-Hung Lin

DOI
https://doi.org/10.1038/s41467-022-31825-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

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Stomatin is a component of lipid rafts. Here, Wu et al. show that stomatin modulates the differentiation and functions of adipocytes by regulating adipogenesis signaling and fatty acid influx such that with excessive calorie intake, increased stomatin induces adiposity.