A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis

Yuting Guan; Xiujie Liang; Ziyuan Ma; Hailong Hu; Hongbo Liu; Zhen Miao; Andreas Linkermann; Jacklyn N. Hellwege; Benjamin F. Voight; Katalin Susztak

doi:10.1038/s41467-021-25377-x

Nature Communications (Aug 2021)

A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis

Yuting Guan,
Xiujie Liang,
Ziyuan Ma,
Hailong Hu,
Hongbo Liu,
Zhen Miao,
Andreas Linkermann,
Jacklyn N. Hellwege,
Benjamin F. Voight,
Katalin Susztak

Affiliations

Yuting Guan: Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania
Xiujie Liang: Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania
Ziyuan Ma: Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania
Hailong Hu: Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania
Hongbo Liu: Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania
Zhen Miao: Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania
Andreas Linkermann: Division of Nephrology, Department of Internal Medicine, University Hospital Carl Gustav Carus at the Technische Universität Dresden
Jacklyn N. Hellwege: Division of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute
Benjamin F. Voight: Department of Genetics, Perelman School of Medicine, University of Pennsylvania
Katalin Susztak: Department of Medicine, Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-021-25377-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Identifying causal variants and genes is an essential step in interpreting GWAS loci. Here, the authors investigate a kidney disease GWAS locus with functional genomics data, CRISPR editing and mouse experiments to identify DPEP1 and CHMP1A as putative kidney disease genes via ferroptosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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