Review of current indications for combined very high fluence collagen cross-linking and laser in situ keratomileusis surgery

Abstract

In this brief review we will discuss the reasoning and evolution of our current use of combined very high-fluence collagen crosslinking and laser in situ keratomileusis. Several presentations and pertinent publications are reviewed, along with the key steps of the enhanced LASIK procedure. Long term outcome data support the safety and efficacy of LASIK Xtra in stabilizing myopic but also hyperopic LASIK results.In conclusion, we have compelling evidence that LASIK Xtra is a safe and effective adjunct.

Keywords

• Epidemiology
• keratoconus
• prevalence
• Disease pathogenesis
• genetic heterogeneity
• genetics and genomics
• genome-wide association study
• genomic loci
• keratoconus
• linkage mapping
• molecular mechanisms
• whole exome-genome sequencing
• Deregulation
• ectasia
• gene expression
• keratoconus
• mass spectroscopy
• proteomics
• signaling pathways
• Cornea
• crosslinking
• keratoconus
• modulus
• Corneal topography
• imaging
• keratoconus
• optical coherence tomography
• placido disc based topography
• Ectatic disease
• keratoconus
• scheimpflug imaging
• Keratoconus
• ocular allergy
• vernal keratoconjunctivitis
• Contact lens
• keratoconus
• piggy back contact lenses
• rigid gas permeable
• scleral lens
• SynergEyes
• toric soft contact lens
• Corneal cross-linking techniques
• new technologies
• riboflavin
• Collagen cross linking
• Corneal collagen cross-linking
• hypoosmolar riboflavin
• keratoconus
• thin cornea
• transepithelial collagen cross-linking
• Corneal cross-linking
• radiant exposure
• ultraviolet-A
• Accelerated corneal cross linking
• keratoconus
• corneal laser surgery
• corneal ectasia
• UV light
• riboflavin
• Laser in situ keratomileusis surgery
• very high fluence collagen cross-linking
• corneal ectosia
• LASIK ectosia prophylaxis