Zaporožskij Medicinskij Žurnal (Apr 2018)

Clinical and pathogenetic value of immune disruptions in manifestation of mixed cryoglobulinemia in patients with chronic hepatitis C

  • O. O. Furyk,
  • Yu. Yu. Riabokon,
  • E. V. Riabokon

DOI
https://doi.org/10.14739/2310-1210.2018.02.124945
Journal volume & issue
no. 2
pp. 188 – 192

Abstract

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Objective – to discover role of immune disorders in clinical manifestations formation of mixed cryoglobulinemia in patients with CHC. Material and methods. 214 patients with CHC were included in the study. The conducted research on frequency of detection and quantitative content of non-organ-specific autoantibodies and circulated immune complexes in reference to presence and degree of the mixed cryoglobulinemia manifestation. Results. It was found that spectrum of autoantibodies was extended in patients with CHC in case of emergence of signs of the mixed cryoglobulinemia. In case of presence of clinical signs of hemorrhagic cryoglobulinemia vasculitis formation. Frequency of IgG cardiolipin detection was 82.1 % in patients with symptoms of Meltzer's triad. RF-IgM in 100 % exceeded this index in patients of other groups (P < 0.01). RF-IgM and RF-IgG quantitative content in the blood serum was the highest (P < 0.01) in patients with CHC and presence of the mixed cryoglobulinemia manifestation in comparison with the patients who had no clinical and biochemical signs or had only biochemical signs of the mixed cryoglobulinemia. Level of IgM and IgG cardiolipin were the highest on condition of hemorrhagic cryoglobulinemia vasculitis (P < 0.01). Progressing of the mixed cryoglobulinemia manifestation was combined with the enlarging (P < 0.01) of CIC quantitative content which correlated with RF-IgM (r=+ 0.36, P < 0.05), IgM cardiolipin (r = +0.38, P < 0.05) and IgG cardiolipin (r = +0.45, P < 0.05). Conclusions. Frequency of detection and quantity of RF-IgM and RF-IgG, IgM cardiolipin and IgG cardiolipin in patients with CHC increases in case of emergence and progressing of the mixed cryoglobulinemia. Increase of non-organ-specific autoantibodies and rise of its quantitative content in patients with CHC in case of emergence and progressing of clinical and biochemical signs of the mixed cryoglobulinemia combines with the rise of CIC in the blood serum which correlates with RF-IgM and RF-IgG, IgM and IgG cardiolipin.

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