Stage-dependent phosphoproteome remodeling of Parkinson's disease blood cells

Giorgia Massacci; Veronica Venafra; Maximilian Zwiebel; Maria Wahle; Rocco Cerroni; Jacopo Bissacco; Livia Perfetto; Vito Michienzi; Alessandro Stefani; Nicola Biagio Mercuri; Tommaso Schirinzi; Francesca Sacco

Neurobiology of Disease (Oct 2024)

Stage-dependent phosphoproteome remodeling of Parkinson's disease blood cells

Giorgia Massacci,
Veronica Venafra,
Maximilian Zwiebel,
Maria Wahle,
Rocco Cerroni,
Jacopo Bissacco,
Livia Perfetto,
Vito Michienzi,
Alessandro Stefani,
Nicola Biagio Mercuri,
Tommaso Schirinzi,
Francesca Sacco

Affiliations

Giorgia Massacci: Department of Biology, University of Rome Tor Vergata, Rome, Italy
Veronica Venafra: PhD Program in Cellular and Molecular Biology, Department of Biology, University of Rome Tor Vergata, Rome, Italy
Maximilian Zwiebel: Department Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
Maria Wahle: Department Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany
Rocco Cerroni: Neurology Unit – Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
Jacopo Bissacco: Neurology Unit – Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
Livia Perfetto: Department of Biology and Biotechnologies ''Charles Darwin'', University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
Vito Michienzi: Neurology Unit – Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
Alessandro Stefani: Neurology Unit – Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
Nicola Biagio Mercuri: Neurology Unit – Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
Tommaso Schirinzi: Neurology Unit – Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Corresponding author at: Department of Systems Medicine, Unit of Neurology University of Roma Tor Vergata, Via Montpellier, 00133 Rome, Italy.
Francesca Sacco: Department of Biology, University of Rome Tor Vergata, Rome, Italy; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Naples, Italy

Journal volume & issue: Vol. 200
p. 106622

Abstract

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The complexity and heterogeneity of PD necessitate advanced diagnostic and prognostic tools to elucidate its molecular mechanisms accurately. In this study, we addressed this challenge by conducting a pilot phospho-proteomic analysis of peripheral blood mononuclear cells (PBMCs) from idiopathic PD patients at varying disease stages to delineate the functional alterations occurring in these cells throughout the disease course and identify key molecules and pathways contributing to PD progression. By integrating clinical data with phospho-proteomic profiles across various PD stages, we identify potential stage-specific molecular signatures indicative of disease progression. This integrative approach allows for the discernment of distinct disease states and enhances our understanding of PD heterogeneity.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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Abstract

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