Nature Communications (May 2021)
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
- Heng-Huan Lee,
- Ying-Nai Wang,
- Wen-Hao Yang,
- Weiya Xia,
- Yongkun Wei,
- Li-Chuan Chan,
- Yu-Han Wang,
- Zhou Jiang,
- Shouping Xu,
- Jun Yao,
- Yufan Qiu,
- Yi-Hsin Hsu,
- Wei-Lun Hwang,
- Meisi Yan,
- Jong-Ho Cha,
- Jennifer L. Hsu,
- Jia Shen,
- Yuanqing Ye,
- Xifeng Wu,
- Ming-Feng Hou,
- Lin-Ming Tseng,
- Shao-Chun Wang,
- Mei-Ren Pan,
- Chin-Hua Yang,
- Yuan-Liang Wang,
- Hirohito Yamaguchi,
- Da Pang,
- Gabriel N. Hortobagyi,
- Dihua Yu,
- Mien-Chie Hung
Affiliations
- Heng-Huan Lee
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Ying-Nai Wang
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Wen-Hao Yang
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Weiya Xia
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Yongkun Wei
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Li-Chuan Chan
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Yu-Han Wang
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Zhou Jiang
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Shouping Xu
- Department of Breast Surgery, Harbin Medical University Cancer Hospital
- Jun Yao
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Yufan Qiu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Yi-Hsin Hsu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Wei-Lun Hwang
- Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University
- Meisi Yan
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Jong-Ho Cha
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Jennifer L. Hsu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Jia Shen
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Yuanqing Ye
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- Xifeng Wu
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- Ming-Feng Hou
- Division of Breast Surgery, Department of Surgery, Kaohsiung Medical University Hospital
- Lin-Ming Tseng
- Comprehensive Breast Health Center and Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital
- Shao-Chun Wang
- Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology, and Center for Molecular Medicine, China Medical University
- Mei-Ren Pan
- Graduate Institute of Clinical Medicine, Kaohsiung Medical University
- Chin-Hua Yang
- Comprehensive Breast Health Center and Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital
- Yuan-Liang Wang
- Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology, and Center for Molecular Medicine, China Medical University
- Hirohito Yamaguchi
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Da Pang
- Department of Breast Surgery, Harbin Medical University Cancer Hospital
- Gabriel N. Hortobagyi
- Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center
- Dihua Yu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Mien-Chie Hung
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-23075-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tumour initiation.
